Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion.

  title={Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion.},
  author={Daniel R Chappell and Nina Doerfler and Matthias Jacob and Markus Rehm and Ulrich Welsch and Peter Conzen and Bernhard Friedrich Becker},
  volume={34 2},
Adhesion of polymorphonuclear neutrophils (PMN) to coronary endothelium is a key event for cardiac ischemia/reperfusion injury. Adhesion molecules are normally harbored within the glycocalyx, clothing every healthy vascular endothelium, but shed by ischemia/reperfusion. Our aim was to show whether protection of the glycocalyx with either hydrocortisone or antithrombin can reduce postischemic leukocyte adhesion. Isolated guinea pig hearts, perfused with Krebs-Henseleit buffer, were subjected to… CONTINUE READING
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Expedition glycocalyx. A newly discovered BGreat Barrier Reef.

D Chappell, M Jacob, +3 authors M Rehm
Anaesthesist 57:959Y969, • 2008

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