Glycocalyx and endothelial (dys) function: from mice to men.

  title={Glycocalyx and endothelial (dys) function: from mice to men.},
  author={Bernard van den Berg and Max Nieuwdorp and Erik S. G. Stroes and Hans Vink},
  journal={Pharmacological reports : PR},
  volume={58 Suppl},
Located on the luminal surface of vascular endothelial cells, the glycocalyx is composed of a negatively charged mesh of proteoglycans, glycosaminoglycans, glycoproteins and glycolipids and harbors a wide array of enzymes that contribute in regulation of leukocyte-/thrombocyte adherence, with a principal role in plasma and vessel wall homeostasis. Glycocalyx disruption is accompanied by enhanced sensitivity of the vasculature towards atherogenic stimuli which emphasizes that not only the… CONTINUE READING
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High resolution 3 D in - travital fluorescence microscopy reveals partial exclusion of anionic tracers within a 1 micron thick capillary endothelial cell glycocalyx

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