Glycoantigens induce human peripheral Tr1 cell differentiation with gut-homing specialization.

@article{Kreisman2011GlycoantigensIH,
  title={Glycoantigens induce human peripheral Tr1 cell differentiation with gut-homing specialization.},
  author={Lori S C Kreisman and Brian A Cobb},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 11},
  pages={8810-8}
}
The carbohydrate antigen (glycoantigen) PSA from an intestinal commensal bacteria is able to down-regulate inflammatory bowel disease in model mice, suggesting that stimulation with PSA results in regulatory T cell (Treg) generation. However, mechanisms of how peripheral human T cells respond and home in response to commensal antigens are still not… CONTINUE READING