Glyco-engineering for the production of recombinant IgA1 with distinct mucin-type O-glycans in plants

@inproceedings{Dicker2016GlycoengineeringFT,
  title={Glyco-engineering for the production of recombinant IgA1 with distinct mucin-type O-glycans in plants},
  author={Martina Dicker and Daniel Maresch and Richard Strasser},
  booktitle={Bioengineered},
  year={2016}
}
IgA nephropathy (IgAN) is a common autoimmune disease that is characterized by formation and deposition of IgA1-containing immune complexes frequently leading to end-stage kidney disease. The IgA1 in these immune complexes carries aberrantly glycosylated O-glycans. In circulating IgA1 these galactose-deficient mucin-type O-glycans are bound by autoantibodies and thus, contribute to immune complex formation and pathogenesis. Even though the disease is associated with the overproduction of… CONTINUE READING
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