Glyco-Engineering of Human IgG-Fc to Modulate Biologic Activities.

  • Roy Jefferis
  • Published 2016 in Current pharmaceutical biotechnology


Advances in genetic and protein engineering and the ability to maintain proliferating mammalian cells in vitro, has allowed reverse engineering of antibodies, i.e. generation of antibodies having specificity for self-antigens. Thus, the lethal consequence of horror autotoxicus, anti-self-responses as envisaged by Paul Ehrlich (1854-1915), has been turned to… (More)
DOI: 10.2174/1389201017666161029225929


Cite this paper

@article{Jefferis2016GlycoEngineeringOH, title={Glyco-Engineering of Human IgG-Fc to Modulate Biologic Activities.}, author={Roy Jefferis}, journal={Current pharmaceutical biotechnology}, year={2016}, volume={17 15}, pages={1333-1347} }