Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in mice.

@article{Norris1992GlycinergicIP,
  title={Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in mice.},
  author={Deborah O. Norris and Joseph Mastropaolo and D. A. O'Connor and M R Novitzki and Stephen I. Deutsch},
  journal={Pharmacology, biochemistry, and behavior},
  year={1992},
  volume={43 2},
  pages={609-12}
}
Milacemide, an acylated prodrug of glycine, was able to increase the efficacy with which [+]-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine meleate (MK 801) antagonized the electrical precipitation of seizures in mice. The mechanism of milacemide's potentiation of MK 801's antiseizure efficacy in intact mice is unclear; however, a glycine agonist selective for the strychnine-insensitive site on the NMDA receptor complex was also able to potentiate MK 801. The exciting possibility… CONTINUE READING

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