Glycine transport accounts for the differential role of glycine vs. d‐serine at NMDA receptor coagonist sites in the salamander retina

@article{Stevens2010GlycineTA,
  title={Glycine transport accounts for the differential role of glycine vs. d‐serine at NMDA receptor coagonist sites in the salamander retina},
  author={Eric R Stevens and Eric C. Gustafson and Robert F. Miller},
  journal={European Journal of Neuroscience},
  year={2010},
  volume={31}
}
In this study, we demonstrate that d‐serine interacts with N‐methyl‐d‐aspartate receptor (NMDAR) coagonist sites of retinal ganglion cells of the tiger salamander retina by showing that exogenous d‐serine overcomes the competitive antagonism of 7‐chlorokynurenic acid for this site. Additionally, we show that exogenous d‐serine was more than 30 times as effective at potentiating NMDAR currents compared with glycine. We thus examined the importance of glycine transport through the application of… Expand
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