Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births

@inproceedings{Redel2016GlycineSI,
  title={Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births},
  author={Bethany K. Redel and Lee D. Spate and Kiho Lee and Jiude Mao and Kristin M Whitworth and Randall S Prather},
  booktitle={Molecular reproduction and development},
  year={2016}
}
Most in vitro culture conditions are less-than-optimal for embryo development. Here, we used a transcriptional-profiling database to identify culture-induced differences in gene expression in porcine blastocysts compared to in vivo-produced counterparts. Genes involved in glycine transport (SLC6A9), glycine metabolism (GLDC, GCSH, DLD, and AMT), and serine metabolism (PSAT1, PSPH, and PHGDH) were differentially expressed. Addition of 10 mM glycine to the culture medium (currently containing 0.1… CONTINUE READING
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1 Arginine supplemtation in vitro increases porcine embryo development and affects mRNA transcript expression

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