Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies.

@article{Takano1997GlycineSA,
  title={Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies.},
  author={Kazue Takano and Turgut Tatlisumak and J E Formato and Richard A. D. Carano and Andreas Bergmann and L. M. Pullan and Thomas M Bare and Christopher H. Sotak and Marc Fisher},
  journal={Stroke},
  year={1997},
  volume={28 6},
  pages={1255-62; discussion 1263}
}
BACKGROUND AND PURPOSE The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid of most side effects associated with competitive and noncompetitive NMDA antagonists. METHODS A novel glycine receptor antagonist, ZD9379, was studied in 70 Sprague-Dawley rats using the… CONTINUE READING