Glycine receptors and glycinergic synaptic transmission in the deep cerebellar nuclei of the rat: a patch-clamp study.

@article{Kawa2003GlycineRA,
  title={Glycine receptors and glycinergic synaptic transmission in the deep cerebellar nuclei of the rat: a patch-clamp study.},
  author={Kazuyoshi Kawa},
  journal={Journal of neurophysiology},
  year={2003},
  volume={90 5},
  pages={3490-500}
}
To clarify possible glycinergic transmission in the cerebellum, principal neurons in deep cerebellar nuclei (DCN) of sliced cerebella (200 microm in thickness) from rats (aged 2-14 days) were studied using whole cell patch-clamp techniques. When glycine (100 microM) was applied to the DCN neurons from a "Y tube," large outward currents were induced (average peak amplitude of about 600 pA at -40 mV). The currents were blocked by strychnine (1 microM) and showed a reversal potential of -62 mV… CONTINUE READING

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