Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men

  title={Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men},
  author={R. Bloomer and Webb A Smith and K. Fisher-Wellman},
  journal={Journal of the International Society of Sports Nutrition},
  pages={22 - 22}
AbstractWe have recently demonstrated that oral intake of glycine propionyl-L-carnitine (GPLC) increases plasma nitrate/nitrite (NOx), a surrogate measure of nitric oxide production. However, these findings were observed at rest, and in previously sedentary subjects.PurposeIn the present study, we sought to determine the impact of oral GPLC on plasma NOx at rest and in response to a period of reactive hyperemia in resistance trained men.MethodsUsing a double blind, crossover design, 15 healthy… Expand

Paper Mentions

Interventional Clinical Trial
To purpose of this study is to assess the effectiveness, safety and tolerability of PEAK ATP® with GlycoCarn®, PEAK ATP® and GlycoCarn® on levels of blood sugar and endothelial function… Expand
ConditionsBlood Sugar, Endothelial Function
InterventionDietary Supplement, Other
Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males
Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics
Effect of betaine supplementation on plasma nitrate/nitrite in exercise-trained men
Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance
Hemodynamic and vascular response to resistance exercise with L-arginine.
Acute Effect of Nitric Oxide Supplement on Blood Nitrate/Nitrite and Hemodynamic Variables in Resistance Trained Men


Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects.
  • R. Bloomer, Lesley C Tschume, Webb A Smith
  • Chemistry, Medicine
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2009
Exercise increases systemic nitric oxide production in men.
Carbohydrate ingestion augments L-carnitine retention in humans.
Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism.
Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm.
Role of nitric oxide in skeletal muscle blood flow at rest and during dynamic exercise in humans.
Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide.
Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease.
Contribution of nitric oxide to exercise‐induced changes in healthy volunteers: effects of acute exercise and long‐term physical training