Glycine metabolism in animals and humans: implications for nutrition and health

@article{Wang2013GlycineMI,
  title={Glycine metabolism in animals and humans: implications for nutrition and health},
  author={Weiwei Wang and Zhenlong Wu and Zhaolai Dai and Ying Yang and Junjun Wang and Guoyao Wu},
  journal={Amino Acids},
  year={2013},
  volume={45},
  pages={463-477}
}
Glycine is a major amino acid in mammals and other animals. It is synthesized from serine, threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the liver and kidneys. Under normal feeding conditions, glycine is not adequately synthesized in birds or in other animals, particularly in a diseased state. Glycine degradation occurs through three pathways: the glycine cleavage system (GCS), serine hydroxymethyltransferase, and conversion to glyoxylate by peroxisomal d… 
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References

SHOWING 1-10 OF 206 REFERENCES
Proline and hydroxyproline metabolism: implications for animal and human nutrition
TLDR
Work with young pigs (a widely used animal model for studying infant nutrition) has shown that supplementing 0.1% proline to a proline-free chemically defined diet dependently improved daily growth rate and feed efficiency while reducing concentrations of urea in plasma.
Functional amino acids in growth, reproduction, and health.
TLDR
Both NEAA and EAA should be considered in the classic "ideal protein" concept or formulation of balanced diets to maximize protein accretion and optimize health in animals and humans.
Glutathione metabolism and its implications for health.
TLDR
Animal and human studies demonstrate that adequate protein nutrition is crucial for the maintenance of GSH homeostasis, and compelling evidence shows that GSH synthesis is regulated primarily by gamma-glutamylcysteine synthetase activity, cysteine availability, and GSH feedback inhibition.
Flux of the l-Serine Metabolism in Rabbit, Human, and Dog Livers
TLDR
Results suggest that SPT/AGT in this organelle plays dual roles in the metabolism of glyoxylate and serine.
Amino acids: metabolism, functions, and nutrition
TLDR
Dietary supplementation with one or a mixture of these functional AA, which include arginine, cysteine, glutamine, leucine, proline, and tryptophan, may be beneficial for ameliorating health problems at various stages of the life cycle and optimizing efficiency of metabolic transformations to enhance muscle growth, milk production, egg and meat quality and athletic performance.
A comparison of alanine and glucose as precursors of serine and glycine.
TLDR
It is suggested that it should be possible to differentiate between these alternative mechanisms by comparing the effect of pteroylglutamic acid deficiency on the biosynthesis of glycine and serine from a non-nitrogenous precursor, such as glucose, since this vitamin deficiency reduces the metabolic interconversion of the two amino acids.
Biochemical and physiological bases for utilization of dietary amino acids by young Pigs
TLDR
This review highlights the basic biochemistry and physiology of absorption and utilization of amino acids in young pigs to enhance the efficacy of utilization of dietary protein and to minimize excretion of nitrogenous wastes from the body.
Dietary requirements of “nutritionally non-essential amino acids” by animals and humans
TLDR
Based on new research findings, NEAA should be taken into consideration in revising the classical “ideal protein” concept and formulating balanced diets to improve protein accretion, food efficiency, and health in animals and humans.
Threonine metabolism in isolated rat hepatocytes.
TLDR
Threonine oxidation is increased by glucagon, which also increases threonine's transport and the majority of threonines oxidation occurs through the glycine-independent threonin dehydratase pathway in rat hepatocytes.
L-serine in disease and development.
TLDR
Recent insights into the role of L-serine and the pathways of L -serine utilization in disease and during development are reviewed, in particular of the central nervous system.
...
...