Glycine metabolism in animals and humans: implications for nutrition and health

  title={Glycine metabolism in animals and humans: implications for nutrition and health},
  author={Weiwei Wang and Zhenlong Wu and Zhaolai Dai and Ying Yang and Junjun Wang and Guoyao Wu},
  journal={Amino Acids},
Glycine is a major amino acid in mammals and other animals. It is synthesized from serine, threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the liver and kidneys. Under normal feeding conditions, glycine is not adequately synthesized in birds or in other animals, particularly in a diseased state. Glycine degradation occurs through three pathways: the glycine cleavage system (GCS), serine hydroxymethyltransferase, and conversion to glyoxylate by peroxisomal d… 
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