Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion.

@article{Dickson1992GlycineCD,
  title={Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion.},
  author={Rolland C. Dickson and Steve F. Bronk and Gregory J. Gores},
  journal={Gastroenterology},
  year={1992},
  volume={102 6},
  pages={2098-107}
}
Glycine protects renal tubule cells from cell death during adenosine triphosphate (ATP) depletion. Although the liver plays a key role in glycine metabolism, information is lacking regarding the effects of glycine on lethal hepatocellular injury. Thus, the aim of this study was to determine the potential cytoprotective role of glycine during ATP depletion of rat hepatocytes. Metabolic inhibition with 2.5 mmol/L potassium cyanide (KCN) was used to produce ATP depletion. Hepatocyte suspensions… CONTINUE READING
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