Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation

@article{Badenhorst2013GlycineCI,
  title={Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation},
  author={Christoffel P. S. Badenhorst and Rencia van der Sluis and Elardus Erasmus and Alberdina Aike van Dijk},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2013},
  volume={9},
  pages={1139 - 1153}
}
Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A (CoASH). However, because of the small number of pharmaceutical drugs that are conjugated to glycine, the pathway has not yet been characterized in detail. Here, we review the causes and possible consequences of interindividual variation in the glycine conjugation pathway… Expand
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TLDR
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