Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.

@article{Naito2014GlycineAG,
  title={Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.},
  author={Anna Naito and Karan H Muchhala and Liana Asatryan and James R. Trudell and Gregg E Homanics and Daya I Perkins and Daryl L Davies and Ronald L. Alkana},
  journal={Molecular pharmacology},
  year={2014},
  volume={86 6},
  pages={635-46}
}
A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To identify the role of individual receptor subunits in ethanol-induced behaviors, we developed a novel class of ultra-sensitive ethanol receptors (USERs) that allow activation of a single receptor subunit population sensitized to extremely low ethanol… CONTINUE READING