Glycine Substitutions in Collagen Heterotrimers Alter Triple Helical Assembly.

@article{Clements2017GlycineSI,
  title={Glycine Substitutions in Collagen Heterotrimers Alter Triple Helical Assembly.},
  author={Katherine A Clements and Amanda M Acevedo-Jake and D R Walker and Jeffrey D Hartgerink},
  journal={Biomacromolecules},
  year={2017},
  volume={18 2},
  pages={617-624}
}
Osteogenesis imperfecta typically results from missense mutations in the collagen genome where the required glycine residues are replaced with another amino acid. Many models have attempted to replicate the structure of mutated collagen on the triple helix level. However, composition and register control of the triple helix is complicated and requires extreme precision, especially when these destabilizing mutations are present. Here we present mutations to a composition- and register-controlled… CONTINUE READING