Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing.

@article{Corti2017GlycineNI,
  title={Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing.},
  author={Angelo Corti and Anna Maria Gasparri and Michela Ghitti and Angelina Sacchi and Francesco Sudati and Martina Fiocchi and Valentina Buttiglione and Laura Perani and Alessandro Gori and S. Valtorta and Rosa Maria Moresco and Fabio Pastorino and Mirco Ponzoni and Giovanna Musco and Flavio Curnis},
  journal={Advanced functional materials},
  year={2017},
  volume={27 36}
}
NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis. Unfortunately, this motif has a strong propensity to undergo rapid deamidation. This reaction, which converts NGR into isoDGR, is associated with receptor switching from CD13 to integrins, with potentially important manufacturing, pharmacological and toxicological implications. It is found that… CONTINUE READING