Glycerolipid metabolism and signaling in health and disease.

  title={Glycerolipid metabolism and signaling in health and disease.},
  author={Marc Prentki and Sri Ramachandra Murthy Madiraju},
  journal={Endocrine reviews},
  volume={29 6},
Maintenance of body temperature is achieved partly by modulating lipolysis by a network of complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty acid (GL/FFA) cycle, which is the focus of this review, and we discuss the significance of this pathway in the regulation of many physiological processes besides thermogenesis. GL/FFA cycle is referred to as a "futile" cycle because it involves continuous formation and hydrolysis of GL with the release of heat, at… CONTINUE READING


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