Glycerol effect on spiramycin production and valine catabolism in Streptomyces ambofaciens

  title={Glycerol effect on spiramycin production and valine catabolism in Streptomyces ambofaciens},
  author={A. Loun{\`e}s and A. Lebrihi and C. Benslimane and G. Lefebvre and P. Germain},
  journal={Current Microbiology},
  • A. Lounès, A. Lebrihi, +2 authors P. Germain
  • Published 2004
  • Biology, Medicine
  • Current Microbiology
  • Spiramycin production by Streptomyces ambofaciens in a chemically defined medium, with valine as nitrogen source, was controlled by the nature and the concentration of the carbon source. The production of this antibiotic was better in dextrins than in glycerol-containing medium. The negative effect of glycerol could be attributed in part to an excess of energy and a high specific growth rate. The intracellular ATP content, at the start of spiramycin production, was twofold higher in glycerol… CONTINUE READING
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