Glyceride Lipid Formulations: Molecular Dynamics Modeling of Phase Behavior During Dispersion and Molecular Interactions Between Drugs and Excipients

@article{Warren2013GlycerideLF,
  title={Glyceride Lipid Formulations: Molecular Dynamics Modeling of Phase Behavior During Dispersion and Molecular Interactions Between Drugs and Excipients},
  author={Dallas B. Warren and Dylan T King and Hassan Benameur and Colin W. Pouton and David K. Chalmers},
  journal={Pharmaceutical Research},
  year={2013},
  volume={30},
  pages={3238-3253}
}
PurposeLittle is known about the microstructure of lipid-based formulations, or how their structure changes as they disperse in the lumen of the gastrointestinal tract. We used molecular dynamics (MD) simulation to study such formulations at the molecular level as they interact with water during dispersion.MethodsWe studied a simple lipid formulation, by itself and in the presence of drugs. The formulation contained mono- and di-lauroyl glycerides at 0–75% w/w water. Acyclovir, danazol… CONTINUE READING
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