Glyceraldehyde-3-phosphate, a glycolytic intermediate, prevents cells from apoptosis by lowering S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase.

@article{Lee2012Glyceraldehyde3phosphateAG,
  title={Glyceraldehyde-3-phosphate, a glycolytic intermediate, prevents cells from apoptosis by lowering S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase.},
  author={Sun Young Lee and Jeong Hoon Kim and Hyeyun Jung and Seung Wook Chi and Sang Jeon Chung and Chong Kil Lee and Byoung Chul Park and K H Bae and Sung Goo Park},
  journal={Journal of microbiology and biotechnology},
  year={2012},
  volume={22 4},
  pages={571-3}
}
Glyceraldehyde-3-phosphate (G-3-P), the substrate of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), is a key intermediate in several metabolic pathways. Recently, we reported that G-3-P directly inhibits caspase-3 activity in a reversible noncompetitive mode, suggesting the intracellular G-3-P level as a cell fate decision factor. It has been known that apoptotic stimuli induce the generation of NO, and NO S-nitrosylates GAPDH at the catalytic cysteine residue, which confers GAPDH the… CONTINUE READING
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