Glyceollin I enantiomers distinctly regulate ER-mediated gene expression

@article{PaytonStewart2010GlyceollinIE,
  title={Glyceollin I enantiomers distinctly regulate ER-mediated gene expression},
  author={Florastina Payton-Stewart and Rahul S. Khupse and S. Boue and S. Elliott and M. Burow},
  journal={Steroids},
  year={2010},
  volume={75},
  pages={870-878}
}
Glyceollins are pterocarpan phytoalexins elicited in high concentrations when soybeans are stressed. We have previously reported that the three glyceollin isomers (GLY I-III) exhibit antiestrogenic properties, which may have significant biological effects upon human exposure. Of the three isomers, we have recently shown that glyceollin I is the most potent antiestrogen. Natural (-)-glyceollin I recently was synthesized along with its racemate and unnatural (+) enantiomer. In this study, we… Expand
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