Glycemic control of apoptosis in the pancreatic beta cell: danger of extremes?

@article{Martens2007GlycemicCO,
  title={Glycemic control of apoptosis in the pancreatic beta cell: danger of extremes?},
  author={Geert A Martens and Mark van de Casteele},
  journal={Antioxidants & redox signaling},
  year={2007},
  volume={9 3},
  pages={309-17}
}
Excessive formation of oxygen radicals is a well-established mediator of hyperglycemic damage in diabetes to a wide range of tissues, such as neurons, retinal cells, and vascular endothelium. Increased oxygen radical formation is generally considered a toxic side effect of excessive rates of mitochondrial oxidative metabolism and electron transport in high glucose-exposed cells. Along the same line, metabolic oxidative stress is currently also regarded as crucial mediator of beta cell… CONTINUE READING

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