Glycation of very low density lipoprotein from rat plasma impairs its catabolism

@article{Mamo1990GlycationOV,
  title={Glycation of very low density lipoprotein from rat plasma impairs its catabolism},
  author={Dr. J. C. L. Mamo and Livia Szeto and George Steiner},
  journal={Diabetologia},
  year={1990},
  volume={33},
  pages={339-345}
}
Rat VLDL were glycated in vitro in the presence or absence of a reducing agent. Prior to glycation, the VLDL triglyceride was endogenously radiolabelled with [3H]-oleic acid. Post glycation the VLDL B-apoprotein was exogenously radiolabelled with [131]I. The double labelled VLDL was then injected into normal rats and the decline in plasma radioactivity of the two isotopes was used as a measure of triglyceride and particle clearance. VLDL glycated in either the presence or absence of reducing… CONTINUE READING
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