Glycation of Lysozyme by Glycolaldehyde Provides New Mechanistic Insights in Diabetes-Related Protein Aggregation.

Abstract

Glycation occurs in vivo as a result of the nonenzymatic reaction of carbohydrates (and/or their autoxidation products) with proteins, DNA, or lipids. Protein glycation causes loss-of-function and, consequently, the development of diabetic-related diseases. Glycation also boosts protein aggregation, which can be directly related with the higher prevalence… (More)
DOI: 10.1021/acschembio.6b01103

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Cite this paper

@article{Mario2017GlycationOL, title={Glycation of Lysozyme by Glycolaldehyde Provides New Mechanistic Insights in Diabetes-Related Protein Aggregation.}, author={Laura Mari{\~n}o and Carlos Andr{\'e}s Maya-Aguirre and Kris Pauwels and Bartolom{\'e} Vilanova and Joaqu{\'i}n Ortega-Castro and Juan Frau and Josefa Donoso and Miquel Adrover}, journal={ACS chemical biology}, year={2017}, volume={12 4}, pages={1152-1162} }