Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma

@article{Backos2013GlycationOG,
  title={Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma},
  author={Donald S. Backos and Kristofer S. Fritz and Debbie G. McArthur and Jadwiga K. Kepa and Andrew M. Donson and Dennis R. Petersen and Nicholas K. Foreman and Christopher C. Franklin and Philip Reigan},
  journal={Neurochemical Research},
  year={2013},
  volume={38},
  pages={1838-1849}
}
The antioxidant glutathione (GSH) plays a critical role in maintaining intracellular redox homeostasis but in tumors the GSH biosynthetic pathway is often dysregulated, contributing to tumor resistance to radiation and chemotherapy. Glutamate-cysteine ligase (GCL) catalyzes the first and rate-limiting reaction in GSH synthesis, and enzyme function is controlled by GSH feedback inhibition or by transcriptional upregulation of the catalytic (GCLC) and modifier (GCLM) subunits. However, it has… 
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