Glycation (non-enzymic glycosylation) inactivates glutathione reductase.

@article{Blakytny1992GlycationG,
  title={Glycation (non-enzymic glycosylation) inactivates glutathione reductase.},
  author={Robert Blakytny and John J. Harding},
  journal={The Biochemical journal},
  year={1992},
  volume={288 ( Pt 1)},
  pages={
          303-7
        }
}
Non-enzymic binding of sugars to proteins (glycation) is a common biological phenomenon that is increased in diabetes. Most work has been directed towards structural proteins which may be present for many years and would continue to accumulate sugar residues. As glycation is a non-specific reaction, other proteins such as enzymes will also be susceptible to glycation and could well display altered activity. We investigated the effect of various sugars whose concentrations increase in diabetes… CONTINUE READING

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