Glycation, ageing and carnosine: Are carnivorous diets beneficial?

@article{Hipkiss2005GlycationAA,
  title={Glycation, ageing and carnosine: Are carnivorous diets beneficial?},
  author={Alan R. Hipkiss},
  journal={Mechanisms of Ageing and Development},
  year={2005},
  volume={126},
  pages={1034-1039}
}
  • A. Hipkiss
  • Published 1 October 2005
  • Biology
  • Mechanisms of Ageing and Development

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Carnosine, a protective, anti-ageing peptide?

  • A. Hipkiss
  • Biology
    The international journal of biochemistry & cell biology
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A possible new role for the anti-ageing peptide carnosine

TLDR
It is proposed, with supporting evidence, that carnosine can react with protein carbonyl groups to produce protein-carbonyl- carnosine adducts (‘carnosinylated’ proteins), which may help explain anti-ageing actions of carnosines and its presence in non-mitotic cells of long-lived mammals.

Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups

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Comparison of nutrition and plasma AGEs in vegetarian and omnivorous groups shows that the higher intake of fructose in alternative nutrition of healthy subjects may cause an increase of AGE levels.

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TLDR
Caloric restriction, which appears to prolong life span by bringing about mild hypoglycemia and increased insulin sensitivity further strengthens the idea that glucose via glycation is the primary damaging molecule.

Carnosine protects proteins against methylglyoxal-mediated modifications.

TLDR
Carnosine can inhibit protein modification induced by a lysine-MG-AGE; this suggests a second intervention site for carnosine and emphasizes its potential as a possible non-toxic modulator of diabetic complications.
...