Glycation, ageing and carnosine: Are carnivorous diets beneficial?

@article{Hipkiss2005GlycationAA,
  title={Glycation, ageing and carnosine: Are carnivorous diets beneficial?},
  author={Alan R. Hipkiss},
  journal={Mechanisms of Ageing and Development},
  year={2005},
  volume={126},
  pages={1034-1039}
}
  • A. Hipkiss
  • Published 1 October 2005
  • Biology
  • Mechanisms of Ageing and Development
View on Elsevier
morelife.org
96 Citations
Background Citations
35
Methods Citations
1

96 Citations

Physiology and pathophysiology of carnosine.

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This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds, and concludes that far more experiments are required to gain a full understanding of the function and applications of this intriguing molecule.

Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease

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The dipeptide carnosine, recently shown to be present in erythrocytes, could help to protect against MG reactivity by scavenging the reactive bicarbonyl, especially if glyoxalase activity is insufficient, as often occurs during aging.

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The importance of carnosine to erythrocyte rheology

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Carnosine, as an antioxidant molecule, protects the erythrocyte from oxidative and peroxidative damage and also protects against oxidative stress induced impairment of RBC deformability.

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

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It is found that both L and D‐CAR greatly reduced obese‐related diseases in obese Zucker rat, by significantly restraining the development of dyslipidaemia, hypertension and renal injury, as demonstrated by both urinary parameters and electron microscopy examinations of renal tissue.

Inhibition of advanced glycation endproduct formation by foodstuffs.

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The development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications.

Carnosine and its possible roles in nutrition and health.

  • A. Hipkiss
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  • 2009

Effect of glycation inhibitors on aging and age-related diseases

Effects of β-Alanine Supplementation and Intramuscular Carnosine Content on Exercise Performance and Health

The effect of 12 weeks carnosine supplementation on renal functional integrity and oxidative stress in pediatric patients with diabetic nephropathy: a randomized placebo‐controlled trial

TLDR
This work investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion, the tubular damage marker alpha 1‐microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy.
...

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  • A. Hipkiss
  • Biology
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TLDR
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Caloric restriction, which appears to prolong life span by bringing about mild hypoglycemia and increased insulin sensitivity further strengthens the idea that glucose via glycation is the primary damaging molecule.

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