96 Citations
Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?
- BiologyAnnals of the New York Academy of Sciences
- 2006
It is suggested that carnivorous diets could be beneficial because of their carnosine content, as the dipeptide has been shown to suppress some diabetic complications in mice and its therapeutic potential should be explored with respect to neurodegeneration.
Physiology and pathophysiology of carnosine.
- BiologyPhysiological reviews
- 2013
This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds, and concludes that far more experiments are required to gain a full understanding of the function and applications of this intriguing molecule.
Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease
- BiologyNeurotoxicity Research
- 2018
The dipeptide carnosine, recently shown to be present in erythrocytes, could help to protect against MG reactivity by scavenging the reactive bicarbonyl, especially if glyoxalase activity is insufficient, as often occurs during aging.
The importance of carnosine to erythrocyte rheology
- Biology
- 2012
Carnosine, as an antioxidant molecule, protects the erythrocyte from oxidative and peroxidative damage and also protects against oxidative stress induced impairment of RBC deformability.
The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats
- Biology, MedicineJournal of cellular and molecular medicine
- 2011
It is found that both L and D‐CAR greatly reduced obese‐related diseases in obese Zucker rat, by significantly restraining the development of dyslipidaemia, hypertension and renal injury, as demonstrated by both urinary parameters and electron microscopy examinations of renal tissue.
Inhibition of advanced glycation endproduct formation by foodstuffs.
- BiologyFood & function
- 2011
The development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications.
Carnosine and its possible roles in nutrition and health.
- BiologyAdvances in food and nutrition research
- 2009
Effect of glycation inhibitors on aging and age-related diseases
- BiologyMechanisms of Ageing and Development
- 2016
References
SHOWING 1-10 OF 110 REFERENCES
Carnosine, a protective, anti-ageing peptide?
- BiologyThe international journal of biochemistry & cell biology
- 1998
A possible new role for the anti-ageing peptide carnosine
- Biology, ChemistryCellular and Molecular Life Sciences CMLS
- 2000
It is proposed, with supporting evidence, that carnosine can react with protein carbonyl groups to produce protein-carbonyl- carnosine adducts (‘carnosinylated’ proteins), which may help explain anti-ageing actions of carnosines and its presence in non-mitotic cells of long-lived mammals.
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups
- Biology, ChemistryMechanisms of Ageing and Development
- 2001
[Carnosine in patients with type I diabetes mellitus].
- Biology, MedicineBratislavske lekarske listy
- 1999
Examination of carnosine in patients with diabetes mellitus type I, showed that the plasma levels of carnitine were non significantly increased compared to the levels in healthy population, while the…
Advanced glycation end products and nutrition.
- Chemistry, MedicinePhysiological research
- 2002
Comparison of nutrition and plasma AGEs in vegetarian and omnivorous groups shows that the higher intake of fructose in alternative nutrition of healthy subjects may cause an increase of AGE levels.
Glucose, glycation and aging
- Biology, MedicineBiogerontology
- 2004
Caloric restriction, which appears to prolong life span by bringing about mild hypoglycemia and increased insulin sensitivity further strengthens the idea that glucose via glycation is the primary damaging molecule.
The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production.
- MedicineMedical hypotheses
- 2005
Carnosine protects proteins against methylglyoxal-mediated modifications.
- BiologyBiochemical and biophysical research communications
- 1998
Carnosine can inhibit protein modification induced by a lysine-MG-AGE; this suggests a second intervention site for carnosine and emphasizes its potential as a possible non-toxic modulator of diabetic complications.
Pyridoxamine, a versatile inhibitor of advanced glycation and lipoxidation reactions
- Biology, Chemistry
- 2002
Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite.
- Biology, ChemistryBiochimica et biophysica acta
- 1998