Glycation, ageing and carnosine: Are carnivorous diets beneficial?

  title={Glycation, ageing and carnosine: Are carnivorous diets beneficial?},
  author={Alan R. Hipkiss},
  journal={Mechanisms of Ageing and Development},
  • A. Hipkiss
  • Published 1 October 2005
  • Biology
  • Mechanisms of Ageing and Development

Physiology and pathophysiology of carnosine.

This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds, and concludes that far more experiments are required to gain a full understanding of the function and applications of this intriguing molecule.

Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease

The dipeptide carnosine, recently shown to be present in erythrocytes, could help to protect against MG reactivity by scavenging the reactive bicarbonyl, especially if glyoxalase activity is insufficient, as often occurs during aging.

The importance of carnosine to erythrocyte rheology

Carnosine, as an antioxidant molecule, protects the erythrocyte from oxidative and peroxidative damage and also protects against oxidative stress induced impairment of RBC deformability.

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

It is found that both L and D‐CAR greatly reduced obese‐related diseases in obese Zucker rat, by significantly restraining the development of dyslipidaemia, hypertension and renal injury, as demonstrated by both urinary parameters and electron microscopy examinations of renal tissue.

Inhibition of advanced glycation endproduct formation by foodstuffs.

The development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications.

Carnosine and its possible roles in nutrition and health.

  • A. Hipkiss
  • Biology
    Advances in food and nutrition research
  • 2009

The effect of 12 weeks carnosine supplementation on renal functional integrity and oxidative stress in pediatric patients with diabetic nephropathy: a randomized placebo‐controlled trial

This work investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion, the tubular damage marker alpha 1‐microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy.



Carnosine, a protective, anti-ageing peptide?

  • A. Hipkiss
  • Biology
    The international journal of biochemistry & cell biology
  • 1998

A possible new role for the anti-ageing peptide carnosine

It is proposed, with supporting evidence, that carnosine can react with protein carbonyl groups to produce protein-carbonyl- carnosine adducts (‘carnosinylated’ proteins), which may help explain anti-ageing actions of carnosines and its presence in non-mitotic cells of long-lived mammals.

Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups

[Carnosine in patients with type I diabetes mellitus].

Examination of carnosine in patients with diabetes mellitus type I, showed that the plasma levels of carnitine were non significantly increased compared to the levels in healthy population, while the

Advanced glycation end products and nutrition.

Comparison of nutrition and plasma AGEs in vegetarian and omnivorous groups shows that the higher intake of fructose in alternative nutrition of healthy subjects may cause an increase of AGE levels.

Glucose, glycation and aging

Caloric restriction, which appears to prolong life span by bringing about mild hypoglycemia and increased insulin sensitivity further strengthens the idea that glucose via glycation is the primary damaging molecule.

Carnosine protects proteins against methylglyoxal-mediated modifications.

Carnosine can inhibit protein modification induced by a lysine-MG-AGE; this suggests a second intervention site for carnosine and emphasizes its potential as a possible non-toxic modulator of diabetic complications.