Glycation, ageing and carnosine: Are carnivorous diets beneficial?

@article{Hipkiss2005GlycationAA,
  title={Glycation, ageing and carnosine: Are carnivorous diets beneficial?},
  author={Alan R. Hipkiss},
  journal={Mechanisms of Ageing and Development},
  year={2005},
  volume={126},
  pages={1034-1039}
}
  • A. Hipkiss
  • Published 1 October 2005
  • Biology
  • Mechanisms of Ageing and Development
Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?
  • A. Hipkiss
  • Biology
    Annals of the New York Academy of Sciences
  • 2006
TLDR
It is suggested that carnivorous diets could be beneficial because of their carnosine content, as the dipeptide has been shown to suppress some diabetic complications in mice and its therapeutic potential should be explored with respect to neurodegeneration.
Physiology and pathophysiology of carnosine.
TLDR
This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds, and concludes that far more experiments are required to gain a full understanding of the function and applications of this intriguing molecule.
Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease
TLDR
The dipeptide carnosine, recently shown to be present in erythrocytes, could help to protect against MG reactivity by scavenging the reactive bicarbonyl, especially if glyoxalase activity is insufficient, as often occurs during aging.
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The importance of carnosine to erythrocyte rheology
TLDR
Carnosine, as an antioxidant molecule, protects the erythrocyte from oxidative and peroxidative damage and also protects against oxidative stress induced impairment of RBC deformability.
The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats
TLDR
It is found that both L and D‐CAR greatly reduced obese‐related diseases in obese Zucker rat, by significantly restraining the development of dyslipidaemia, hypertension and renal injury, as demonstrated by both urinary parameters and electron microscopy examinations of renal tissue.
Inhibition of advanced glycation endproduct formation by foodstuffs.
TLDR
The development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications.
Carnosine and its possible roles in nutrition and health.
  • A. Hipkiss
  • Biology
    Advances in food and nutrition research
  • 2009
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  • A. Hipkiss
  • Biology
    The international journal of biochemistry & cell biology
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TLDR
It is proposed, with supporting evidence, that carnosine can react with protein carbonyl groups to produce protein-carbonyl- carnosine adducts (‘carnosinylated’ proteins), which may help explain anti-ageing actions of carnosines and its presence in non-mitotic cells of long-lived mammals.
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Comparison of nutrition and plasma AGEs in vegetarian and omnivorous groups shows that the higher intake of fructose in alternative nutrition of healthy subjects may cause an increase of AGE levels.
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Caloric restriction, which appears to prolong life span by bringing about mild hypoglycemia and increased insulin sensitivity further strengthens the idea that glucose via glycation is the primary damaging molecule.
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TLDR
Carnosine can inhibit protein modification induced by a lysine-MG-AGE; this suggests a second intervention site for carnosine and emphasizes its potential as a possible non-toxic modulator of diabetic complications.
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