Glycated albumin activates PAI-1 transcription through Smad DNA binding sites in mesangial cells.

Abstract

Amadori-modified glycated albumin stimulates extracellular matrix and transforming growth factor-beta (TGF-beta) expression in cultured mesangial cells. Smad proteins transduce the TGF-beta-mediated signal, and Smad-binding CAGA sequences are present in the plasminogen activator inhibitor-1 (PAI-1) promoter. This study examined whether glycated albumin… (More)

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@article{Lee2004GlycatedAA, title={Glycated albumin activates PAI-1 transcription through Smad DNA binding sites in mesangial cells.}, author={Hyun Soon Lee and Kyung Chul Moon and Chi Young Song and Bong Cho Kim and Suxia Wang and Hye Kyoung Hong}, journal={American journal of physiology. Renal physiology}, year={2004}, volume={287 4}, pages={F665-72} }