Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox.

@article{Li2010GlycatedAA,
  title={Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox.},
  author={Yanzhang Li and Shuxia Wang},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={397 1},
  pages={5-11}
}
Glycated albumin, an early-glycation Amadori-modified protein, stimulates transforming growth factor-beta (TGF-beta) expression and increases the production of the extracellular matrix proteins in mesangial cells, contributing to the pathogenesis of diabetic nephropathy. Glycated albumin has been shown to increase NADPH oxidase-dependent superoxide formation in mesangial cells. However, the mechanisms are not well understood. Therefore, in the present studies, we determined the mechanisms by… CONTINUE READING

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