Glycans in post-Golgi apical targeting: sorting signals or structural props?

@article{RodriguezBoulan1999GlycansIP,
  title={Glycans in post-Golgi apical targeting: sorting signals or structural props?},
  author={Enrique Rodriguez-Boulan and Augusto Gonz{\'a}lez},
  journal={Trends in cell biology},
  year={1999},
  volume={9 8},
  pages={291-4}
}
A recent model proposed that N-glycans serve as apical targeting signals for soluble and membrane proteins in epithelial cells and neurons by interacting with lectin sorters in the trans-Golgi network. However, we believe that a number of experimental observations support an alternative hypothesis, that N-glycans play a facilitative role, by providing structural support or preventing aggregation of the proteins for example, thereby allowing interaction of proteinaceous apical sorting signals… CONTINUE READING

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