Glycans in cancer and inflammation — potential for therapeutics and diagnostics

  title={Glycans in cancer and inflammation — potential for therapeutics and diagnostics},
  author={Danielle H. Dube and Carolyn R. Bertozzi},
  journal={Nature Reviews Drug Discovery},
Changes in glycosylation are often a hallmark of disease states. For example, cancer cells frequently display glycans at different levels or with fundamentally different structures than those observed on normal cells. This phenomenon was first described in the early 1970s, but the molecular details underlying such transformations were poorly understood. In the past decade advances in genomics, proteomics and mass spectrometry have enabled the association of specific glycan structures with… 

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