Glycan-dependent signaling: O-linked N-acetylglucosamine.

  title={Glycan-dependent signaling: O-linked N-acetylglucosamine.},
  author={John A Hanover},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={15 11},
  • John A Hanover
  • Published 2001 in
    FASEB journal : official publication of the…
The addition of O-linked N-acetylglucosamine (O-GlcNAc) to target proteins may serve as a signaling modification analogous to protein phosphorylation. Like phosphorylation, O-GlcNAc is a dynamic modification occurring in the nucleus and cytoplasm. Various analytical methods have been developed to detect O-GlcNAc and distinguish it from glycosylation in the endomembrane system. Many target molecules have been identified; these targets are typically components of supramolecular complexes such as… CONTINUE READING


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