Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury

@article{Quint2014GlycandependentBO,
  title={Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury},
  author={H{\'e}ctor R Quint{\'a} and Juana Mar{\'i}a Pasquini and Gabriel A. Rabinovich and Laura A. Pasquini},
  journal={Cell Death and Differentiation},
  year={2014},
  volume={21},
  pages={941-955}
}
Following spinal cord injury (SCI), semaphorin 3A (Sema3A) prevents axonal regeneration through binding to the neuropilin-1 (NRP-1)/PlexinA4 receptor complex. Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI. Although both Gal-1 and its monomeric variant… CONTINUE READING
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