Glycan analysis of Prostate Specific Antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS.

@article{Behnken2014GlycanAO,
  title={Glycan analysis of Prostate Specific Antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS.},
  author={Henning N Behnken and Alexandra Ruthenbeck and Jan-Mirco Schulz and Bernd Meyer},
  journal={Journal of proteome research},
  year={2014},
  volume={13 2},
  pages={997-1001}
}
Glycans are important modulators of the biological function of proteins and are normally characterized from proteolytic glycopeptides or from (N-)glycans released enzymatically by glycosidase treatment or chemically by hydrazinolysis. We demonstrate that glycan compositions can easily be determined directly by LC-ESI/TOF-MS from intact glycoproteins even with a very complex glycosylation pattern. Interpretation of isotopically resolved mass spectra of prostate specific antigen (PSA) using… CONTINUE READING
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