Glycaemic efficacy of glucagon‐like peptide‐1 receptor agonists and dipeptidyl peptidase‐4 inhibitors as add‐on therapy to metformin in subjects with type 2 diabetes—a review and meta analysis

@article{Deacon2012GlycaemicEO,
  title={Glycaemic efficacy of glucagon‐like peptide‐1 receptor agonists and dipeptidyl peptidase‐4 inhibitors as add‐on therapy to metformin in subjects with type 2 diabetes—a review and meta analysis},
  author={Carolyn F. Deacon and Edoardo Mannucci and Bo Ahr{\'e}n},
  journal={Diabetes},
  year={2012},
  volume={14}
}
Aims: During recent years, two strategies of incretin‐based therapy [glucagon‐like peptide‐1 (GLP‐1) receptor agonism and dipeptidyl peptidase‐4 (DPP‐4) inhibition] have entered the market for pharmacological management of type 2 diabetes. A main indication for this therapy is as add‐on to on‐going metformin therapy in subjects with type 2 diabetes who have insufficient glycaemic control with metformin alone. The aim of this study was to compare improvements in glycaemic control and changes in… 

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...

References

SHOWING 1-10 OF 45 REFERENCES

Dipeptidyl Peptidase‐4 Inhibitors Administered in Combination With Metformin Result in an Additive Increase in the Plasma Concentration of Active GLP‐1

TLDR
The study results show that metformin is not a DPP‐4 inhibitor but rather enhances precursor GCG expression in the large intestine, resulting in increased total GLP‐1 concentrations, which have complementary mechanisms of action and additive effects with respect to increasing the concentrations of active GLP-1 in plasma.

Incretin‐based therapies – review of the physiology, pharmacology and emerging clinical experience

TLDR
In this review, aspects of incretin biology and pharmacotherapy are addressed with a view to highlighting potentially clinically relevant issues and areas of basic research that may impinge on these.

Incretin based therapies for type 2 diabetes mellitus.

TLDR
Therapeutic approaches for enhancing the incretin action include degradation resistant GLP-1 receptor agonists (incretin mimetics) and inhibitors of dipeptidyl peptidase-IV (DLP-IV) activity (Incretin enhancers- gliptins).

Efficacy and safety of adding the dipeptidyl peptidase‐4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double‐blind, placebo‐controlled study

Aims:  To evaluate the efficacy and safety of alogliptin, a new dipeptidyl peptidase‐4 inhibitor, for 26 weeks at once‐daily doses of 12.5 and 25 mg in combination with metformin in patients whose

Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus

TLDR
This 18‐week, phase 3b, multicentre, double‐blind, noninferiority trial compared the efficacy and safety of two dipeptidyl peptidase‐4 inhibitors, saxagli leptin and sitagliptin, in patients whose glycaemia was inadequately controlled with metformin.

Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin

  • B. Ahrén
  • Medicine
    Vascular health and risk management
  • 2008
TLDR
Both fasting and prandial glucose are reduced by DPP-4 inhibition in combination with metformin in association with improvement of insulin secretion and insulin resistance and increase in concentrations of active GLP-1.

Efficacy and Safety of Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Compared with Exenatide Twice Daily and Sitagliptin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

TLDR
Compared with other incretin-based therapies, LA-GLP-1RAs produce greater improvement in A1C and FPG and result in a potentially favorable adverse event profile compared with exenatide twice daily.

Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

TLDR
In patients with type 2 diabetes, near maximal glucose-lowering efficacy of sitagliptin after single oral doses was associated with inhibition of plasma DPP-4 activity of 80% or greater, corresponding to a plasma sitgliptin concentration of 100 nm or greater and an augmentation of active GLP-1 and GIP levels of 2-fold or higher after an OGTT.

Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin

  • B. Ahrén
  • Medicine, Biology
    Diabetes, metabolic syndrome and obesity : targets and therapy
  • 2010
TLDR
Sitagliptin has in several clinical studies been shown to improve metabolic control in type 2 diabetes, both when used as monotherapy and when used in combination with metformin, sulfonylurea, thiazolidinediones or insulin.