Glyc-oxidized LDL impair endothelial function more potently than oxidized LDL: role of enhanced oxidative stress.

@article{Galle1998GlycoxidizedLI,
  title={Glyc-oxidized LDL impair endothelial function more potently than oxidized LDL: role of enhanced oxidative stress.},
  author={Jan Galle and Ralf Schneider and Beate Winner and C Lehmann-Bodem and Reinhard Schinzel and G M{\"u}nch and Ernst Conzelmann and Christoph Wanner},
  journal={Atherosclerosis},
  year={1998},
  volume={138 1},
  pages={65-77}
}
Hypercholesterolemia is associated with impairment of endothelial function due to increased levels of LDL. In diabetic patients, however, attenuation of endothelial function occurs even under normocholesterolemic conditions. Here we assessed whether glycation of LDL potentiates their influence on endothelial function, with particular emphasis on the oxidizability of LDL and the role of O2-. Human LDL was glycated by dialyzation for 7 days against buffer containing 200 mmol/l glucose, or sham… CONTINUE READING