GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.

Abstract

Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR alpha3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that GlyR alpha3 is distinctly expressed in superficial layers of the spinal cord… (More)

Topics

Cite this paper

@article{Harvey2004GlyRAA, title={GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.}, author={Robert J Harvey and Ulrike B Depner and Heinz W{\"a}ssle and Seifollah Ahmadi and Cornelia Heindl and Heiko Reinold and Trevor G Smart and Kirsten Harvey and Burkhard Sch{\"{u}tz and Osama M. Abo-Salem and Andreas D. Zimmer and Pierrick Poisbeau and Hans Welzl and David P Wolfer and Heinrich Betz and Hanns Ulrich Zeilhofer and Ulrike Mueller}, journal={Science}, year={2004}, volume={304 5672}, pages={884-7} }