GlyCAM-1 supports leukocyte rolling in flow: evidence for a greater dynamic stability of L-selectin rolling of lymphocytes than of neutrophils.

@article{Dwir1998GlyCAM1SL,
  title={GlyCAM-1 supports leukocyte rolling in flow: evidence for a greater dynamic stability of L-selectin rolling of lymphocytes than of neutrophils.},
  author={Oren Dwir and Frida Shimron and C Chen and Mark S. Singer and S D Rosen and Ronen Alon},
  journal={Cell adhesion and communication},
  year={1998},
  volume={6 4},
  pages={349-70}
}
L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules (HEV). We have investigated the role of GlyCAM-1, a major L-selectin ligand produced by HEV, in mediating leukocyte rolling under in vitro flow conditions. Purified GlyCAM-1 was found to support tethering and rolling in physiological shear flow of both human and murine L-selectin expressing leukocytes at an efficiency comparable to the HEV-derived L-selectin ligands termed peripheral node addressin… CONTINUE READING

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