Gluten sensitivity and 'normal' histology: is the intestinal mucosa really normal?

  title={Gluten sensitivity and 'normal' histology: is the intestinal mucosa really normal?},
  author={Andrea Sbarbati and Enrico Valletta and Marco Bertini and Marco Cipolli and Manrico Morroni and L Pinelli and Luciano Tat{\`o}},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  volume={35 11},
BACKGROUND Early pathogenetic events of gluten intolerance may be overlooked in patients with serologic markers of celiac disease and normal intestinal mucosa by both conventional histology and immunohistochemistry. AIMS To investigate if a submicroscopical damage of the absorptive cell surface was associated with developing gluten sensitivity. PATIENTS AND METHODS Duodenal biopsies of seven subjects with positive anti-endomysial antibodies and normal histology underwent ultrastructural… CONTINUE READING