Gluten Sensitivity in Pediatrics: A Clinical Conundrum

@article{Cristofori2014GlutenSI,
  title={Gluten Sensitivity in Pediatrics: A Clinical Conundrum},
  author={Fernanda Cristofori and Francesca Arezzo and Antonia Gentile and Ruggiero Francavilla},
  journal={Current Pediatrics Reports},
  year={2014},
  volume={2},
  pages={204-210}
}
AbstractNon-celiac gluten sensitivity (NCGS) is a condition in which symptoms are triggered by gluten ingestion, in which both allergic and autoimmune mechanisms have been ruled out. The “classical” presentation of NCGS is a combination of gastrointestinal symptoms (including abdominal pain, bloating, and bowel habit abnormalities) and extra-intestinal manifestations. So far, NCGS has been described extensively in adults, and few data are available for the pediatric population. Due to lack of… 

References

SHOWING 1-10 OF 48 REFERENCES

Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders

TLDR
The major advances and current trends on Non Celiac Gluten sensitivity are reported, including an overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria.

Non-Celiac Wheat Sensitivity Is Not a New Entity

TLDR
It seems that non-celiac wheat or gluten sensitivity may not be an entity but a syndrome as there is some evidence that the pathogenesis of this non-CEliac gluten sensitivity is diverse in different patients.

Non-celiac gluten sensitivity.

Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity.

  • C. BucciF. Zingone C. Ciacci
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2013

Serological Tests in Gluten Sensitivity (Nonceliac Gluten Intolerance)

TLDR
The serological pattern of GS is characterized by IgG AGA positivity in more than half of cases associated to IgA AGA in a few patients, but without EmA, tTGA, and DGP-AGA, which are the specific markers of celiac disease.

Clinical, Serologic, and Histologic Features of Gluten Sensitivity in Children

TLDR
The diagnosis of gluten sensitivity was made after symptoms were associated with wheat ingestion despite a negative celiac disease evaluation, and all children included in this case series tested negative for IgA endomysial antibodies, IgA tissue transglutaminase antibodies, wheat-specific IgE, gluten-specific antibodies, skin prick testing to wheat, and atopy patch testing to Wheat.

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

TLDR
This review will summarize the current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.

Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!

TLDR
In this month's edition of the American Journal of Gastroenterology, evidence is seen to support the clinical concept of wheat sensitivity or intolerance that may be adopted internationally by clinicians.

Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit

TLDR
This large retrospective study on children with food induced gastrointestinal allergies highlights the variety of symptoms and treatment modalities used in these children, however, further prospective studies are required in this area of food allergy.

Gluten-sensitive diarrhea without evidence of celiac disease.