Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial

@article{Biesiekierski2011GlutenCG,
  title={Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial},
  author={Jessica R. Biesiekierski and E D Newnham and Peter M. Irving and Jacqueline Susanne Barrett and Melissa Haines and James D Doecke and Susan Joy Shepherd and Jane G. Muir and Peter R. Gibson},
  journal={The American Journal of Gastroenterology},
  year={2011},
  volume={106},
  pages={508-514}
}
OBJECTIVES:Despite increased prescription of a gluten-free diet for gastrointestinal symptoms in individuals who do not have celiac disease, there is minimal evidence that suggests that gluten is a trigger. The aims of this study were to determine whether gluten ingestion can induce symptoms in non-celiac individuals and to examine the mechanism.METHODS:A double-blind, randomized, placebo-controlled rechallenge trial was undertaken in patients with irritable bowel syndrome in whom celiac… 
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