Glutathionylation regulates IkappaB.

  title={Glutathionylation regulates IkappaB.},
  author={In Sup Kil and Sung Youl Kim and Jeen-Woo Park},
  journal={Biochemical and biophysical research communications},
  volume={373 1},
Although there has been considerable interest in the regulation of NFkappaB activation by glutathionylation, the possibility of IkappaB as a target for glutathionylation has not been investigated. We now report that Cys(189) of IkappaB alpha is a target for S-glutathionylation. This modification is reversed by thiols such as dithiothreitol and GSH. The glutathionylated IkappaB alpha appears to be significantly less susceptible than is native protein to phosphorylation by IkappaB kinase and… CONTINUE READING