Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.

  title={Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.},
  author={Xinyu Wang and Xiaopan Cai and Jingjing Hu and Naimin Shao and Fei Wang and Qiang Zhang and Jianru Xiao and Yiyun Cheng},
  journal={Journal of the American Chemical Society},
  volume={135 26},
Polymeric nanoparticles that can stably load anticancer drugs and release them in response to a specific trigger such as glutathione are of great interest in cancer therapy. In the present study, dendrimer-encapsulated gold nanoparticles (DEGNPs) were synthesized and used as carriers of thiolated anticancer drugs. Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and… 

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