Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.

  title={Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.},
  author={Xinyu Wang and Xiaopan Cai and Jingjing Hu and Naimin Shao and Fei Wang and Qiang Zhang and Jianru Xiao and Yiyun Cheng},
  journal={Journal of the American Chemical Society},
  volume={135 26},
Polymeric nanoparticles that can stably load anticancer drugs and release them in response to a specific trigger such as glutathione are of great interest in cancer therapy. In the present study, dendrimer-encapsulated gold nanoparticles (DEGNPs) were synthesized and used as carriers of thiolated anticancer drugs. Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and… 

Figures from this paper

Imaging-Guided Drug Release from Glutathione-Responsive Supramolecular Porphysome Nanovesicles.

Supramolecular porphysome nanovesicles that were self-assembled by amphiphilic porphyrin derivatives were successfully constructed, mainly driven by the π-π stacking, hydrogen bonding, and hydrophobic interactions, and were used as carriers of anticancer drugs.

pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

The results demonstrate that the ATRAM-BSA-PLGA NPs are a promising targeted cancer drug delivery platform that display both in vitro and in vivo efficacy while evading recognition by macrophages.

Enzyme-Sensitive and Amphiphilic PEGylated Dendrimer-Paclitaxel Prodrug-Based Nanoparticles for Enhanced Stability and Anticancer Efficacy.

These nanoparticles exhibited significantly enhanced antitumor efficiency in the 4T1 breast cancer model as indicated by the observed inhibition of angiogenesis and proliferation as well as induction of apoptosis, and may potentially serve as nanoscale vehicles for breast cancer therapy.

A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6‑mercaptopurine.

Dual-Responsive Polymer Micelles for Target-Cell-Specific Anticancer Drug Delivery

This study develops a dual-responsive polymer micelle system with sheddable polyethylenimine (PEI) shells for actively targeted drug delivery that exhibits an ultrasensitive negative-to-positive charge reversal in response to the extracellular pH value, resulting in greatly enhanced uptake by cancer cells via electrostatic interaction.

Design and characterization of dual responsive mesoporous silica nanoparticles for breast cancer targeted therapy.

  • D. BhavsarV. PatelK. Sawant
  • Biology, Chemistry
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2020

Dual Stimuli-Responsive Nanoparticles for Controlled Release of Anticancer and Anti-inflammatory Drugs Combination.

This study reports the pH/redox dual responsive nanoparticle FA-DOX-Ind-NP based on the novel tumor targeting and biodegradable poly(β-amino ester) polymer and demonstrates its high ability to enter into cancer cells and release a combination of the anticancer drug doxorubicin and the non-steroidal anti-inflammatory drug indomethacin to achieve synergistic chemo-anti-inflammatory effects and overcome multidrug resistance.

Glutathione conjugated superparamagnetic Fe3O4-Au core shell nanoparticles for pH controlled release of DOX.




Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells.

DOX-Hyd@AuNPs represents a model with dual roles in overcoming MDR in cancer cells and probing the intracellular release of drug from its delivery system.

Gold-doxorubicin nanoconjugates for overcoming multidrug resistance.

Real-time monitoring of glutathione-triggered thiopurine anticancer drug release in live cells investigated by surface-enhanced Raman scattering.

In vitro and in vivo glutathione (GSH)-induced intracellular thiopurine anticancer drug release on gold nanoparticle (Au NP) surfaces is investigated by means of label-free confocal Raman spectroscopy and demonstrates that the time-lapse Ramans spectroscopic tools are useful for monitoring of the controlled release of thioporine drug molecules in vitro andIn vivo.

Polymeric nanoparticles with encapsulated superparamagnetic iron oxide and conjugated cisplatin for potential bladder cancer therapy.

Pt-Fe-PNs are potentially a promising cisplatin delivery vehicle which can be combined with SPIONs-induced hyperthermia for bladder cancer therapy and can effectively induce cytotoxicity against UMUC3 bladder cancer cells with IC(50) of 32.3 μM.

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives.

This critical review focuses on the design of biocompatible dendrimer-based nanoplatforms for targeted cancer diagnosis and therapy and theBiocompatibility aspects of d endrimers such as nanotoxicity, long-term circulation, and degradation are discussed.

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

The remarkable antitumor activity of dendrimer–DOX results from the ability of the d endrimer to favorably modulate the pharmacokinetics of attached DOX.

Development of self-immolative dendrimers for drug delivery and sensing.

Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity, and low cost.

This study demonstrated that disulfide cross-linked low generation PAMAM dendrimers with high transfection efficacy, low cytotoxicity, and low cost are efficient alternatives to high generation PamAM d endrimers in gene delivery.

Encapsulation and stabilization of gold nanoparticles with "click" polyethyleneglycol dendrimers.

Both 1,2,3-triazole and PEGylated Percec-type dendrons are required in the dendrimer structure for the stabilization of AuNPs upon NaBH( 4) reduction of HAuCl(4) in methanol and stabilization of DSAuNPs.