Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas.

  title={Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas.},
  author={Henry W. J. Lin and Nicole Probst-Hensch and Sue Ann Ingles and Chi Young Han and Bruce K. Lin and David B. N. Lee and Harold D. Frankl and Eric C. Lee and Matthew Paul Longnecker and Robert W Haile},
  journal={Cancer research},
  volume={55 6},
Colorectal cancer is caused by environmental exposures and genetic predisposition. However, little is known of hereditary factors that influence development of common, non-Mendelian forms of this cancer. Interactions among carcinogen exposure, hereditary variants of enzymes involved in carcinogen metabolism, and other host factors may play a role. Genetic polymorphisms of carcinogen metabolism, such as the glutathione transferase M1 (GSTM1) null genotype, are thus possibly related to cancer… CONTINUE READING
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