Glutathione synthetase promotes the reduction of arsenate via arsenolysis of glutathione.

@article{Nmeti2012GlutathioneSP,
  title={Glutathione synthetase promotes the reduction of arsenate via arsenolysis of glutathione.},
  author={Bal{\'a}zs N{\'e}meti and Mary E Anderson and Zolt{\'a}n Gregus},
  journal={Biochimie},
  year={2012},
  volume={94 6},
  pages={1327-33}
}
The environmentally prevalent arsenate (As(V)) undergoes reduction in the body to the much more toxic arsenite (As(III)). Phosphorolytic enzymes and ATP synthase can promote the reduction As(V) by converting it into arsenylated products in which the pentavalent arsenic is more reducible by glutathione (GSH) to As(III) than in inorganic As(V). Glutathione synthetase (GS) can catalyze the arsenolysis of GSH (γ-Glu-Cys-Gly) yielding two arsenylated products, i.e. γ-Glu-Cys-arsenate and ADP… CONTINUE READING

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