Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter.

@article{Vayalil2007GlutathioneST,
  title={Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter.},
  author={Praveen Kumar Vayalil and Karen E. Iles and Jinah Choi and A E Yi and Edward M. Postlethwait and Rui-ming Liu},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 5},
  pages={L1281-92}
}
Transforming growth factor (TGF)-beta upregulates plasminogen activator inhibitor type 1 (PAI-1) in a variety of cell types, and PAI-1 is considered to be an essential factor for the development of fibrosis. Our previous studies demonstrated that TGF-beta decreased intracellular glutathione (GSH) content in murine embryonic fibroblasts (NIH/3T3 cells), whereas treatment of the cells with GSH, which restored intracellular GSH concentration, inhibited TGF-beta-induced collagen accumulation by… CONTINUE READING