Glutathione supplementation improves macrophage functions in HIV.

  title={Glutathione supplementation improves macrophage functions in HIV.},
  author={Devin Morris and Carlos Gustavo Guerra and Melissa Khurasany and Frederick Timothy Guilford and Beatrice Saviola and Ying Huang and Vishwanath Venketaraman},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={33 5},
In this study, we determined the effects of glutathione (GSH)-enhancing agents in restoring the levels of GSH in isolated macrophages from individuals with HIV infection thereby resulting in improved control of Mycobacterium tuberculosis. Our results indicate that treatment with N-acetyl cysteine or a liposomal formulation of glutathione (lGSH) resulted in replenishment of reduced also known as free GSH (rGSH), and correlated with a decrease in the intracellular growth of M. tuberculosis… CONTINUE READING