Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

@article{Laliberte2003GlutathioneSO,
  title={Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.},
  author={Ronald E Laliberte and David G Perregaux and Lise R. Hoth and Philip J Rosner and Crystal K Jordan and Kevin M Peese and James F Eggler and Mark A Dombroski and Kieran F. Geoghegan and Christopher A. Gabel},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={16567-78}
}
Stimulus-induced posttranslational processing of human monocyte interleukin-1beta (IL-1beta) is accompanied by major changes to the intracellular ionic environment, activation of caspase-1, and cell death. Certain diarylsulfonylureas inhibit this response, and are designated cytokine release inhibitory drugs (CRIDs). CRIDs arrest activated monocytes so that caspase-1 remains inactive and plasma membrane latency is preserved. Affinity labeling with [(14)C]CRIDs and affinity chromatography on… CONTINUE READING