Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen.

@article{Vayalil2005GlutathioneRC,
  title={Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen.},
  author={Praveen Kumar Vayalil and Mitchell A. Olman and Joanne E Murphy-Ullrich and Edward M. Postlethwait and Rui-ming Liu},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={289 6},
  pages={L937-45}
}
Transforming growth factor (TGF)-beta plays an important role in tissue fibrogenesis. We previously demonstrated that reduced glutathione (GSH) supplementation blocked collagen accumulation induced by TGF-beta in NIH-3T3 cells. In the present study, we show that supplementation of GSH restores the collagen degradation rate in TGF-beta-treated NIH-3T3 cells… CONTINUE READING